"In 1889 the Reading Railroad announced it would build a new train depot for its Philadelphia services on the corner of 12th and Market Streets. Reading announced that the new depot would include a new trainshed, advertised to be the biggest in the world, fronted on Market by an eight-story headhouse, which would serve as the passenger station and company headquarters for the Reading Railroad."
it's now part of the Convention Center; that's a Hard Rock Cafe on the lower left.
Taken from the 13th floor of a nearby office building

Ref: 64

Location: 12th & Market Sts, Philadelphia

Photographer: MooCat